PROCESS FOR THE PREPARATION OF 3-AMINO-5-HYDROXYBE

专利名称：PROCESS FOR THE PREPARATION OF 3-AMINO-5-HYDROXYBENZOIC ACIDS ANDDERIVATIVES AND ANALOGUES THEREOF

发明人：RICKARDS, Rodney, Warren,BECKER, Anna,

Maria,BROWN, Roger, Frederich, Challis

申请号：EP83902635.0申请日：19830822公开号：EP0134782A1公开日：19850327

摘要： Process for preparing compounds of general formula (2), wherein R1represents -OR2 or NR3R4 radicals; and wherein R2, R3, R4, R5, R6 and R7 are radicalsseparately selected from hydrogen and alkyl, or their acid addition salts, comprising: a)reacting a 3,5-dihydroxybenzoic acid of general formula ( 3) with a compound of generalformula (4) where R3, R4, R5, R6, and R7 are defined as before, to produce a compound ofgeneral formula (2b), wherein R3, R4, R5, R6 and R7 are defined as before; and, whenpreparing compounds of general formula (2) wherein R1 represents the radical -OR 2,further comprising b) hydrolyzing the compound of general formula (2b) to produce acarboxylic acid of general formula (2c) which R3, R4, R5, R6 and R7 are defined as before;and c) esterification of the acid of general formula (2c) to produce an ester of the generalformula (2d) where R2 is alkyl and R3, R4, R5, R6 and R7 are defined as before; or, whenpreparing compounds of general formula (2) wherein R1 represents -OR2 radical and R 2an alkyl, including d) esterification of the amide of general formula (2b) in acid to producean ester of general formula (2d).

申请人：THE AUSTRALIAN NATIONAL UNIVERSITY

地址：Acton, Australian Capital Territory 2600 AU

国籍：AU

代理机构：Collier, Jeremy Austin Grey

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